TCA cycle,Krebs cycle,citric acid cycle and its energy calculation.

Krebs cycle / TCA Cycle / Citric acid cyclcle

In the anaerobic pathway of glycolysis, glucose is oxidised to pyruvate. Then, pyruvate is metabolised to acetyl coA .

Further metabolism of acetyl coA to Co2 and H2O occurs in citric acid cycle. It is an aerobic pathway. The reactions of citric acid cycle are as follows .

TCA Cycle , citric acid cycle , Krebs cycle, Biochemistry notes


The reaction of citric acid cycle are as follows-

1. Acetyl CoA to citrate-

Acetyl coA combines with oxaloacetate to form citrate.This reaction is catalysed by the enzyme citrate synthase.

2. Citrate to isocitrate-

The two steps of the reaction are citrate is dehydrated to aconitate and aconitate is rehydrated to form isocitrate.This reaction is catalysed by the enzyme aconitase.

3. Isocitrate to oxalosuccinate-

Dehydogenetion of isocitrate from oxalosuccinate.it catalysed by the enzyme isocitrate dehydrogenase.

4. Oxalosuccinate to alpha ketoglutarate-

Oxalosuccinate is decarboxylated tw no form alpha ketoglutarate.it is catalysed by the enzyme isocitrate dehydrogenase.

5. Alpha ketoglutarate to succinyl CoA-

Oxidative carboxylation of alpha ketoglutarate forms succinyl coA.it catalysed by the enzyme alpha ketoglutarate dehydrogenase.

6. Succinyl CoA to Succinate-

In this reaction succinyl CoA is converted to succinate.it is catalysed by the enzyme succinate thiokinase.

7. Succinate to fumarate-

Dehydrogenetion of succinate form fumarate.it is catalysed by the enzyme succinate dehydrogenase.

8. Fumarate to malate-

In this reaction fumarate is converted to malate. it is catalysed by the enzyme fumarase.

9. Malate to oxaloacetate-

In this reaction malate is converted to oxaloacetate. This reaction is catalysed by the enzyme malate dehydrogenase.



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